Table 2.
Multivariate Cox Analysis | EFS from date of diagnosis | OS from date of diagnosis | ||||
---|---|---|---|---|---|---|
Somatic Alterations at Diagnosis | HR | 95% CI | p | HR | 95% CI | p |
0-1 | 1 | 1 | ||||
2 or more | 2.65 | 1.27-5.54 | 0.01 | 3.13 | 1.39-7.01 | 0.006 |
Age at diagnosis (months) | ||||||
<24 | 1 | 1 | ||||
>24 | 1.62 | 0.82-3.21 | 0.167 | 1.55 | 0.73-3.28 | 0.25 |
Platelet count at diagnosis ×109 | ||||||
≥40 | 1 | 1 | ||||
<40 | 1.64 | 0.86-3.08 | 0.128 | 2.19 | 1.09-4.39 | 0.028 |
Fetal hemoglobin at diagnosis | ||||||
Not elevated for age | 1 | 1 | ||||
Elevated for age | 1.56 | 0.81 -3.02 | 0.184 | 0.93 | 0.69-2.80 | 0.355 |
NF1 status | ||||||
No | 1 | 1 | ||||
Yes | 0.85 | 0.38 1.93 | 0.7 | 0.5 | 0.19-1.29 | 0.15 |