Table 2.

Multivariate analysis of prognostic variables in JMML.

Multivariate Cox Analysis	EFS from date of diagnosis			OS from date of diagnosis
Somatic Alterations at Diagnosis	HR	95% CI	p	HR	95% CI	p
0-1	1			1
2 or more	2.65	1.27-5.54	0.01	3.13	1.39-7.01	0.006
Age at diagnosis (months)
<24	1			1
>24	1.62	0.82-3.21	0.167	1.55	0.73-3.28	0.25
Platelet count at diagnosis ×109
≥40	1			1
<40	1.64	0.86-3.08	0.128	2.19	1.09-4.39	0.028
Fetal hemoglobin at diagnosis
Not elevated for age	1			1
Elevated for age	1.56	0.81 -3.02	0.184	0.93	0.69-2.80	0.355
NF1 status
No	1			1
Yes	0.85	0.38 1.93	0.7	0.5	0.19-1.29	0.15