Table 1.
Effect of EPL on hemodynamic parameters
| Treatment groups | SAP (mmHg) | DAP (mmHg) | MAP (mmHg) | HR (BPM) | ST elevation (mV) |
|---|---|---|---|---|---|
| Normal | 112.3±13.0 | 87.67±06.40 | 88.17±05.80 | 324.6±61.90 | 0.028±0.02 |
| ISO | 78.87±11.3## | 51.33±20.10### | 50.67±19.00### | 295.00±29.10 | 0.088±0.01### |
| EPL (50) | 89.00±09.60 | 67.67±16.50* | 71.50±16.20* | 381.2±73.90 | 0.050±0.02* |
| EPL (100) | 105.20±10.80** | 84.83±17.20*** | 84.50±16.90** | 366.5±19.20 | 0.038±0.01*** |
| EPL (150) | 111.3±7.50*** | 85.67±17.40*** | 86.77±17.40*** | 328.4±53.90 | 0.032±0.004*** |
Data was expressed as mean ± SEM
##
p<0.01 as compared to normal;
###
p<0.001 as compared to normal;
*
p<0.05 as compared to ISO, Significance was determined by One-Way ANOVA followed by Dunnet Post-hoc test;
**
p<0.01 as compared to ISO, Significance was determined by One-Way ANOVA followed by Dunnet Post-hoc test;
***
p<0.001 as compared to ISO, Significance was determined by One-Way ANOVA followed by Dunnet Post-hoc test.
SBP: systolic blood pressure, DBP: diastolic blood pressure, MBP: mean blood pressure, HR: heart rate. ISO: isoproterenol; EPL: eplerenone. The figure in the parenthesis indicates the dose in mg/kg.