Table 1.
Correlations between WISP-1 expression and clinicopathologic features in patients with pancreatic ductal adenocarcinoma (PDA)
| Clinicopathologic feature | Total 194 | Expression of WISP-1 | P value (χ2 test) | |
|---|---|---|---|---|
|
| ||||
| Low (n=95, 49.0%) | High (n=99, 51.0%) | |||
| Age (years) | ||||
| ≤65 | 103 | 48 (46.6) | 55 (53.4) | 0.483 |
| >65 | 91 | 47 (51.6) | 44 (48.4) | |
| Gender | ||||
| Male | 111 | 54 (48.6) | 57 (51.4) | 0.918 |
| Female | 83 | 41 (49.4) | 42 (50.6) | |
| Clinical stage (AJCC) | ||||
| I | 22 | 12 (54.5) | 10 (45.5) | 0.003 |
| II | 127 | 71 (55.9) | 56 (44.1) | |
| III | 33 | 11 (33.3) | 22 (66.7) | |
| IV | 12 | 1 (8.3) | 11 (91.7) | |
| Size | ||||
| ≤ 2 cm | 27 | 13 (48.1) | 14 (51.9) | 0.927 |
| >2 cm | 167 | 82 (49.1) | 85 (50.9) | |
| T classification | ||||
| T1 | 3 | 0 (0.0) | 3 (100.0) | 0.008 |
| T2 | 22 | 15 (68.2) | 7 (31.8) | |
| T3 | 130 | 68 (52.3) | 62 (47.7) | |
| T4 | 39 | 12 (30.8) | 27 (69.2) | |
| N classification | ||||
| Absent | 133 | 67 (50.4) | 66 (49.6) | 0.563 |
| Present | 61 | 28 (45.9) | 33 (54.1) | |
| Liver metastasis | ||||
| Absent | 181 | 93 (51.4) | 88 (48.6) | 0.012 |
| Present | 13 | 2 (15.4) | 11 (84.6) | |
| Vascular invasion | ||||
| Absent | 169 | 79 (46.7) | 90 (53.3) | 0.107 |
| Present | 25 | 16 (64.0) | 9 (36.0) | |
| Tumor location | ||||
| Head | 131 | 68 (51.9) | 63 (48.1) | 0.238 |
| Body/tail | 63 | 27 (42.9) | 36 (57.1) | |
| Histological differentiation | ||||
| Well | 11 | 6 (54.5) | 5 (45.5) | 0.703 |
| Moderate/poor | 183 | 89 (48.6) | 94 (51.4) | |
Values in parentheses indicate percentage values. The bold number represents the P-values with significant differences. AJCC staging is according to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system.