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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Addict Biol. 2015 Apr 29;21(4):802–810. doi: 10.1111/adb.12258

Figure 1. Cocaine-sired male offspring have increased anxiety-like behavior.

Figure 1

Data are expressed as latency (s, mean ± SEM) to consume peanut butter chips in a familiar or novel environment during a 15-minute test session. A) Cocaine-sired male offspring (n=10 animals, selected from 8 litters) show increased latency to feed compared to saline-sired male offspring (n=9 rats, selected from 9 litters). B) There is no difference between cocaine-sired (n=10 rats, 9 litters) and saline-sired (n=9 rats, 9 litters) female offspring latency to feed in the novel environment. * p<0.001 for cocaine-sired vs. saline-sired latency in the novel environment. C) Cocaine-sired male offspring (n=12 animals, 9 litters) spend more time burying compared to saline-sired male offspring (n=10 animals, 9 litters). D) There is no difference in burying time between cocaine-sired (n=10 rats, 9 litters) and saline-sired (n=9 rats, 7 litters) female offspring. # p<0.05 comparing siring.