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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Addict Biol. 2015 Apr 29;21(4):802–810. doi: 10.1111/adb.12258

Figure 2. Acute cocaine increases latency to feed in a novel environment.

Figure 2

A) Animals received 0 (n=4), 2.5 mg/kg (n=4), or 5 mg/kg (n=4) cocaine (i.p.) 30 minutes prior to all test sessions. Cocaine dose-dependently increased latency to feed in the novel environment, but not in the homecage. B) Animals received the 2.5 mg/kg dose of cocaine (i.p.) 30 minutes prior to all testing sessions. Cocaine (n=6 animals, selected from 5 litters) significantly increased latency to feed in saline-sired male offspring relative to saline injection (n=9 rats, 8 litters). C) Pre-exposure to 2.5 mg/kg cocaine (n=6 animals, selected from 6 litters) did not enhance latency to feed compared to cocaine-sired male offspring treated with saline (n=10 animals, 9 litters). D) Paternal cocaine experience did not influence immobility, swimming or climbing in the male offspring during a forced swim test. Data are represented as counts (mean ± SEM) of immobility, swimming, or climbing behaviors recorded every 5 seconds during a 5 minute forced swim (n=10 rats, 6 litters for each group). * p<0.01, ** p<0.001.