Figure 6.

Bacterial load in mice lungs and decrease in pial capillary density 6 h after infection. Panel A shows that the bacterial concentrations in lungs of mice infected with the ExoU-producing PA103 strain or with the PA103ΔexoU mutant did not differ from each other. Data represent means and SEM of the results obtained in eight mice infected with each bacteria, assessed in two different assays. Panel B shows the decrease in cerebral capillary density in infected mice, considering the mean number of capillaries/mm² of control mice as 100%. The decrease in mice infected with PA103 was significantly higher (P < 0.05, as determined by the Mann Whitney test). Data are mean (and SEM) of the results obtained in five mice infected with each bacteria.