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FIM biogenesis. The FimC protein is predicted to be an integral outer membrane (om) β-barrel usher protein. FimB is predicted to function as a chaperone that binds FimD, Fim2 and Fim3 proteins, preventing their degradation in the periplasm and directing them to FimC for translocation across the om. Within FimC, the FimB chaperone transfers the fimbrial subunit to the next subunit in the channel by donor strand exchange, resulting in elongation of the FIM structure.
