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. 2015 Oct 30;3:68. doi: 10.3389/fcell.2015.00068

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Copyright © 2015 Fierro, O'Neal, Beegle, Chávez, Peavy, Isseroff and Egaña.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSC-containing SDR secrete VEGF, SDF-1α, and induce migration of CD34⁺ H/EPC in vitro. (A) MSC-containing SDR were incubated with medium changes every second day. At every medium change, supernatants were collected, and VEGF and SDF-1α protein levels measured by ELISA. Average of MSC from 3 different donors are shown. (B) Supernatant of SDR (control) and SDR + MSC were collected after 48 h incubation and tested for CD34⁺ H/EPC migration in a transwell assay, as described in the Materials and Methods Section. In addition, AMD3100 (100 ng/ml) was added to the SDR + MSC condition during the transwell assay. Average of CD34⁺ of 3 different donors using MSCs from 2 different donors are shown. ^*p < 0.05.