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. 2015 Oct 10;7(10):4067–4082. doi: 10.3390/toxins7104067

Figure 4.

Figure 4

In vitro activity of dDTEGF13 against negative control Raji cells. To study the selectivity of dDTEGF13, EGFR−IL-13− Raji cells (human Burkitts’ lymphoma cell line) were studied in a proliferation assay based on 3H thymidine uptake. No inhibition of proliferation was seen with DTEGF13, dDTEGF13, DTIL13, DTEGF and DTCD3CD3. However, inhibition did occur with control DT2219ARL because DT2219 consists of DT spliced to anti-CD19 and anti-CD22scFvs. Raji expresses both CD19 and CD22. These data indicate activity is mediated through the selective ligand binding.