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. 2015 Oct 10;7(10):4067–4082. doi: 10.3390/toxins7104067

Figure 5.

Figure 5

The immunogenicity of dDTEGF13. The immune response to deimmunized and non-mutated parental drug was determined by measuring anti-DT390 serum IgG on weekly samples of mice immunized with 0.25 µg of DTEGF13 (n = 5) or dDTEGF13 7 (n = 5). Measurements were made using an indirect ELISA and quantification of antibodies was determined using a standard curve generated with highly purified, high titer anti-DT antibody. Response was determined in BALB/c mice (* = P < 0.03) (A) and C57BL/6 mice (* = P < 0.01; # = P < 0.05) (B).