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. 2015 Oct 10;7(10):4067–4082. doi: 10.3390/toxins7104067

Figure 6.

Figure 6

Neutralizing antibodies. Serum was collected from mice immunized with multiple injections of (A) parental DTEGF13 or (B) dDTEGF13 on day 56. Serum from individual mice was incubated with MiaPaCa-2 cells treated with a known inhibitory concentration of DTEGF13 in order to test for neutralization. Proliferation assays were performed by measuring tritiated thymidine uptake after 72 h. The serum concentration of IgG anti-toxin that was measured for each serum on day 56 is shown (μg/mL). There is a correlation between serum levels and the presence of neutralizing antibody.