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Peptidomimetics of ShK that contain the (a) 2-aminobenzimidazole scaffold, compounds 40 and 41 [89]; and (b) the N-alkylated indole-7-carboxamido scaffold, compound 42 [90]. The scaffold structure is highlighted in blue. Activity was determined using a voltage-gated Kv1.3 potassium channels patch clamp assay.
