Figure 5.

Ultrasound evaluation of ovulatory failure in women. An ovarian follicle in a woman receiving placebo was at 19 mm diameter on the day of the LH peak (A) and showed decreased follicular diameter (follicle collapse; consistent with follicle rupture) on the day after peak LH (B). An ovarian follicle in a woman receiving the PTGS2 inhibitor rofecoxib was at 22 mm diameter on the day of peak LH (C) and was at 50 mm diameter on Day 10 after peak LH (D). With PTGS2 inhibitor treatment, the follicle continued to increase in diameter after the LH surge (no follicle collapse; failure of follicle rupture). In these ultrasound images, ovarian follicles are black circles, with dotted lines to indicate measurement of follicular diameters. All panels are at approximately the same magnification. Republished with permissions from Pall et al. (2001).