Table 3.
Results From Univariate Unadjusted and Multivariable Adjusted Cox Proportional Hazards Models for the Association Between Eradication Status and Time to Chronic and Mucoid Pseudomonas aeruginosa
| Variable | HR | 95% CI | P Value |
|---|---|---|---|
| Time to chronic Pa (unadjusted) | |||
| Nonsustained eradicator | … | … | … |
| Sustained eradicator | 0.26 | (.17–.40) | <.001 |
| Time to chronic Pa (adjusted multivariable model) | |||
| Nonsustained eradicator | … | … | … |
| Sustained eradicator | 0.21 | (.13–.33) | <.001 |
| Age at trial completion | |||
| <6 y | … | … | … |
| 6 to <10 y | 1.31 | (.73–2.36) | .359 |
| ≥10 y | 1.78 | (1.00–3.19) | .052 |
| Pa history prior to trial enrollment | |||
| No lifetime history of Pa positivity | … | … | … |
| Lifetime history of Pa positivity | 1.69 | (1.01–2.82) | .046 |
| Treatment regimen received during the trial | |||
| Culture-based therapy | … | … | … |
| Cycled therapy | 1.60 | (1.02–2.53) | .042 |
| Time to mucoid Pa (unadjusted) | |||
| Nonsustained eradicator | … | … | … |
| Sustained eradicator | 0.43 | (.25–.73) | .002 |
| Time to mucoid Pa (adjusted multivariable model) | |||
| Nonsustained eradicator | … | … | … |
| Sustained eradicator | 0.36 | (.20–.63) | <.001 |
| Age at trial completion | |||
| <6 y | … | … | … |
| 6 to <10 y | 1.84 | (.84–4.00) | .126 |
| ≥10 y | 3.26 | (1.52–6.98) | .002 |
| Pa history prior to trial enrollment | |||
| No lifetime history of Pa positivity | … | … | … |
| Lifetime history of Pa positivity | 1.96 | (1.06–3.63) | .032 |
| Treatment regimen received during the trial | |||
| Culture-based therapy | … | … | … |
| Cycled therapy | 1.30 | (.75–2.26) | .345 |
Abbreviations: CI, confidence interval; HR, hazard ratio; Pa, Pseudomonas aeruginosa.