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. 2015 Oct 30;6:251. doi: 10.3389/fphar.2015.00251

Figure 1.

Figure 1

Effect of fentanyl on basic synaptic transmission in the hippocampal CA1 area. (A) The amplitude of fEPSPs was increased by fentanyl exposure (30 min, solid horizontal bar) in a dose-dependent manner. However, the elevated fEPSPs response was completely restored after a 60 min washout. Fen-0.01: 0.01 μM fentanyl; Fen-0.1: 0.1 μM fentanyl; Fen-1: 1 μM fentanyl. (B) In the slices with pretreatment of 50 μM picrotoxin (Pic, open bar, for at least 30 min), fentanyl exposure and washout did not change basic synaptic transmission. (C) In the presence of 10 μM CTOP (open bar), fentanyl exposure and washout did not change basic synaptic transmission. (D) Basic synaptic transmission among the indicated groups was calculated by an average of fEPSP amplitudes during baseline (0–10 min) and the last 10 min of fentanyl exposure (30–40 min). *p < 0.05, **p < 0.01 baseline vs. 30–40 min. Data presented as mean ± SEM. N = 8–12 per group from five rats.