Skip to main content
. 2015 Oct 30;6:251. doi: 10.3389/fphar.2015.00251

Figure 4.

Figure 4

Effect of fentanyl exposure and washout on LTP in the hippocampal CA1 area in the presence of 10 μM CTOP (open bar, 10 min before fentanyl/vehicle treatment). (A) Hippocampal LTP was recorded after 30 min fentanyl (1 μM) exposure and 60 min washout in the indicated groups. (B) Hippocampal LTD was recorded after 30 min fentanyl (1 μM) exposure and 60 min washout in the indicated groups. (C) LTP and LTD among indicated groups were calculated by an average of fEPSP amplitudes and comparisons were made between baseline (0–20 min) and the last 10 min of recordings (70–80 min). NS, non-significance CTOP/Vehicle vs. CTOP/Fen-1 group. Data presented as mean ± SEM. N = 8–10 per group from six rats. Inserts show representative traces of fEPSP in slices treated with CTOP/vehicle (black) or CTOP/1 μM fentanyl (red) before tetanus stimulation (solid line) and at the end of 1 h recording (dash line); scale bars represent 5 ms and 0.5 mV, respectively.