Table 5. Normalized Cross-Correlation Values between the 7HC Ring and Selected Regions of GRY53/7HC–Ligand Complexesa.
GRY53/7HC–croconate complex |
GRY53/7HC–glucuronate complex |
||
---|---|---|---|
region | averaged correlated movement with 7HC | region | averaged correlated movement with 7HC |
helix 1 (Res 74–79) | 0.10 ± 0.06 | helix 1 (Res 74–79) | 0.13 ± 0.04 |
helix 2 (Res 82–87) | 0.2 ± 0.1 | helix 2 (Res 82–87) | 0.2 ± 0.1 |
entire protein (Res 1–262) | 0.0 ± 0.2 | entire protein (Res 1–262) | 0.0 ± 0.2 |
The normalized values of the DCCM are given where a value of −1 indicates residue movements are perfectly anticorrelated, and a value of +1 indicates residue movements are perfectly correlated. A strong correlation is seen in the movement of the 7HC ring with helix 1 (residues 74–79) and helix 2 (residues 82–87) in both the GRY53/7HC–croconate and GRY53/7HC–glucuronate complexes. There is no statistically significant correlation in the movement of the 7HC ring with all residues, as expected.