Figure 5. Expected number of metastases generated from both type-1 and type-2 cells in different size categories.

The number of metastatic sites of the indicated sizes upon diagnosis on the x-axis by computational simulation (dots) and theoretical formulas (lines) when the primary tumor is diagnosed at (A) 1–3 cm and (B) 4–6 cm in diameter. Parameter values used are r = 0.11, d = 0.01r, a₁ = 0.16, b₁ = 0.01a₁, a₂ = 0.24, b₂ = 0.01a₂, a₃ = 0.58, b₃ = 0.01a₃, u₁ = u₂ = 6.31×10⁻⁵, and q = q′ = 6.31×10⁻⁷, which are based on the estimation using time series clinical data in the pancreatic cancer autopsy program.