Figure 6. Probability of metastasis generated from both type-1 and type-2 cells in different size categories.

Panels show the probabilities of existence of metastases of the indicated sizes upon diagnosis on the x-axis, with the assumption that the number of metastatic sites follows an exponential distribution with the mean of the expected numbers of the categories. “Large” denotes a metastatic site larger than 2.5 cm, “medium” denotes between 0.5 cm and 2.5 cm, “small” denotes between 0.1 cm and 0.5 cm, and “micro” denotes less than 0.1 cm. The diameter of the primary tumor upon diagnosis is (A) 1–3 cm and (B) 4–6 cm. Parameter values used are based on the estimation in the autopsy program: r = 0.11, d = 0.01r, a₁ = 0.16, b₁ = 0.01a₁, a₂ = 0.24, b₂ = 0.01a₂, a₃ = 0.58, b₃ = 0.01a₃, u₁ = u₂ = 6.31×10⁻⁵, and q = q′ = 6.31×10⁻⁷.