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. 2015 Oct 30;5:15883. doi: 10.1038/srep15883

Figure 6. LMP7 deficiency attenuates inflammatory responses in adipose tissues.

Figure 6

(A) Representative images of immunostaining for F4/80 in epididymal WAT of WT and LMP7−/− mice. (B) Quantitative analysis of F4/80-positive areas (n = 9–10). (C) Representative images of infiltrated macrophages (CD11+F4/80+ and F4/80+CCR2+) in epididymal WAT of HFD-fed WT and LMP7−/− mice by flow cytometry analysis. (D) Quantitative analysis of infiltrated macrophages (CD11+F4/80+ and F4/80+CCR2+) and CD8+ T cells (CD8+CD3+) in epididymal WAT of HFD-fed WT and LMP7−/− mice (n = 5–7 for each). (E) Gene expression in epididymal WAT of HFD-fed WT and LMP7−/− mice (n = 8 for each). (F) Expression of macrophage M1 markers (Cd80, Cd86, and Nos2) and M2 markers (Cd163, Cd206, Arg1, and Chil3) in epididymal WAT of HFD-fed WT and LMP7−/− mice (n = 4 for each). (G,H) Serum adiponectin and leptin levels in WT and LMP7−/− mice on normal chow and HFD (n = 8 for each). Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01.