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. 2015 Oct 27;6(6):e01428-15. doi: 10.1128/mBio.01428-15

FIG 4 .

FIG 4 

Type II ME49 Toxoplasma infection leads to spontaneous seizures in mice. (A and B) Examples of EEG and EMG recordings from control (left column) and type II ME49-infected (right column) mice. Data represent 2 EEG traces and 1 EMG trace that were obtained simultaneously from each animal and are shown in a time-locked state. The recordings represented in panel A show 60 s of neural and muscular activity in control and type II ME49-infected mice. The recordings represented in panel B show 120 s of neural and muscular activity in control and type II ME49-infected mice. (C) EMG recordings from control (left column) and type II ME49-infected (right column) mice. Note that motor seizures persisted for as long as 15 min in this type II ME49-infected mouse. (D) Quantification of the number of seizure events that exceeded 30 s in the 5-day recording period. Bar graph data represent means ± SEM. Circles represent individual data points. P < 0.05 (Tukey-Kramer HSD test). (E) Individual and sparse spikes of neural and muscular activity were observed at similar frequencies in mock-infected and type II ME49-infected mice. (F) Quantification of the number of spiking events in the 5-day recording period. Bar graph data represent means ± SEM. Circles represent individual data points. The numbers of spikes seen with mock-infected mice were not statistically significantly different from those seen with type II ME49-infected mice (P > 0.1 [Tukey-Kramer HSD test]).