FIG 5 .

Increased susceptibility of type II ME49 Toxoplasma-infected mice to drug-induced seizures. (A) Five days after mice were analyzed for spontaneous seizures, they were injected with PTZ (40 mg/kg), and EEG/EMG data were recorded for 15 min. The data shown represent typical EMG traces from a mock-infected mouse (top) and a type II ME49 parasite-infected mouse (bottom). Notice the increased strength and intensity of muscular activity in the type II ME49 Toxoplasma-infected mouse. (B) Averages (± SEM) of seizure score data recorded every minute for 15 min after injection of PTZ. n = 5 mice for wild-type mice and 9 for type II ME49 mice. *, P < 0.05 (unpaired, two-tailed t test).