Table 6.
Correlation between the endocrine disruptors concentration in blood/serum and nuclear receptors gene expression in infertile and fertile subjects (Spearman’s rank correlation test, Bonferroni corrected). (a) Fertile subjects; (b) Infertile subjects.
| (a) | ||||
| Chemicals | PFOA | PFOS | MEHP | BPA |
| Nuclear Receptors | ||||
| ERα | –0.51 * | 0.04 | –0.17 | 0.53 * |
| ERβ | –0.46 * | 0.02 | –0.2 | 0.51 * |
| AR | –0.49 * | 0.02 | –0.18 | 0.53 * |
| AhR | –0.31 * | 0.19 | –0.23 | 0.42 * |
| PXR | –0.52 * | 0.08 | –0.14 | 0.61 * |
| PPARγ | 0.12 | 0.22 | 0.04 | –0.34 |
| (b) | ||||
| Chemicals | PFOA | PFOS | MEHP | BPA |
| Nuclear Receptors | ||||
| ERα | –0.76 * | 0.04 | 0.02 | 0.51 * |
| ERβ | –0.75 * | 0.04 | 0.03 | 0.49 * |
| AR | –0.74 * | 0.03 | 0.01 | 0.50 * |
| AhR | –0.69 * | 0.20 | –0.02 | 0.50 * |
| PXR | –0.76 * | 0.05 | 0.07 | 0.50 * |
| PPARγ | 0.34 | –0.19 | –0.09 | 0.33 |
* Indicates statistically significant correlation. PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonate; MEHP, mono-(2-ethylhexyl)-phthalate; BPA, bisphenol A; ERα, estrogen receptor α; ERβ, estrogen receptor β; AR, androgen receptor; PPAR γ, peroxisome proliferator-activated receptor γ; AhR, aryl hydrocarbon receptor; PXR, pregnane X receptor.