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. 2015 Apr 23;43(19):9314–9326. doi: 10.1093/nar/gkv324

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Olfr mRNAs are ARE-rich. (A) ARE pentamer density measured in silico. (B) Density distribution plot of the number of AUUUA ARE pentamers, assessed as in panel (A). (C) Scatterplots and linear regression analysis of expression level versus AUUUA pentamer density, assessed as in panel A. (D) Schematic of luciferase and renilla reporters used. (E,F) Two Olfr 3′ UTRs influence mRNA steady-state level and mRNA half-life in response to CCR4B depletion (using a siRNA targeting CCR4B [siCcr4b]) and CCR4B overexpression (using a CCR4B expression vector). Panel E is measurement of relative mRNA levels (RQ) and panel (F) is measurement of relative luciferase values (RLU). *P < 0.05; n.s. not significant.