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. 2015 Oct 7;43(19):9327–9339. doi: 10.1093/nar/gkv908

Figure 6.

Figure 6.

Oncostatin M induces apoptosis in ACC cells. (A) Schematic representation of a canonical oncostatin M signaling pathway. Downregulated genes from the oncostatin M signaling pathway identified by the genome-wide integrated analysis are highlighted in green. Oncostatin M inhibits cell proliferation (B and C) and apoptosis (D and E) by increased caspase 3/7 activity in a dose-dependent manner in NCI-H295R (B and D) and BD140A cells (C and E). It induces apoptosis by stimulating the JAK-STAT signaling cascade and cleavage of PARP and caspase 3 in ACC NCI-H295R cells (F).