Table 3. List of canonical pathways that are altered in ACC.
| Ingenuity Canonical Pathways | -log(P-value) | Ratio | Molecules |
|---|---|---|---|
| Methylation | |||
| LXR/RXR activation | 3.94E + 00 | 3.91E − 02 | APOC1, CD14, PLTP, CLU, ABCA1 |
| 3-phosphoinositide synthesis and degradation | 2.63E + 00 | 2.67E − 02 | MTMR6, PTPN13, PPTC7, PPP1R14A |
| Oncostatin M signaling | 2.15E + 00 | 5.88E − 02 | IL6ST, JAK1 |
| PI3K/AKT signaling | 1.92E + 00 | 2.34E − 02 | JAK1, ITGA2, MAP3K5 |
| Cdc42 signaling | 1.60E + 00 | 1.78E − 02 | ITGA2, HLA-DPB1, CLIP1 |
| ERK/MAPK signaling | 1.47E + 00 | 1.57E − 02 | ITGA2, PPP1R14A, RAPGEF4 |
| Copy number | |||
| Aryl hydrocarbon receptor signaling | 4.55E + 00 | 3.57E − 02 | NCOA2, ALDH3A2, GSTA4, RARA, GSTA1 |
| LPS/IL-1 mediated inhibition of RXR function | 2.63E + 00 | 1.83E − 02 | ALDH3A2, GSTA4, RARA, GSTA1 |
| EIF2 signaling | 1.09E + 00 | 1.08E − 02 | RPL8, EIF3M |
| Axonal guidance signaling | 1.01E + 00 | 6.94E − 03 | ACTR3, SDCBP, COPS5 |
| Glucocorticoid receptor signaling | 8.43E − 01 | 7.66E − 03 | CDKN1C, NCOA2 |
| miRNA | |||
| Protein ubiquitination pathway | 3.90E + 00 | 3.14E − 02 | HSP90B1, UBE2H, HSPE1, HSP90AA1, UBE2E3, SKP1, DNAJB14, USP33 |
| Nitric oxide signaling | 3.54E + 00 | 5.05E − 02 | CALM1 (includes others), HSP90B1, PRKAR2B, HSP90AA1, PDGFC |
| PI3K/AKT signaling | 3.11E + 00 | 4.07E − 02 | ITGB1, RPS6KB1, HSP90B1, FOXO1, HSP90AA1 |
| IL-8 signaling | 2.35E + 00 | 2.73E − 02 | MYL9, RPS6KB1, RHOB, IQGAP1, PDGFC |
| Aryl hydrocarbon receptor signaling | 2.04E + 00 | 2.86E − 02 | RB1, HSP90B1, NCOA7, HSP90AA1 |
| Cdc42 signaling | 1.78E + 00 | 2.40E − 02 | ITGB1, MYL9, CFL2, IQGAP1 |
| mTOR signaling | 1.01E + 00 | 1.60E − 02 | RPS6KB1, RHOB, PDGFC |
| Oncostatin M signaling | 1.17E + 00 | 5.70E − 02 | IL6ST, EPAS1 |
The lists of genes that are potentially regulated by methylation, copy number and miRNA and are involved in each molecular pathway are tabulated with its significance as obtained from IPA network analysis.