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. 2015 Sep 22;43(19):9133–9146. doi: 10.1093/nar/gkv910

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — TP53 Mutation signatures for lung cancer. (A) Mutation signature for smokers showing the probability for different mutation types at relevant trinucleotides. The trinucleotide sequences used in the study are marked with an asterisk. (B) Mutation signatures for non-smokers. (C) Difference between smokers and non-smokers for G:C>T:A mutation probabilities. Trinucleotide sequences used in this study are labelled. (D) Plot of G:C>T:A probabilities at relevant trinucleotides in smokers against probability differences between smokers and non-smokers.