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. 2015 Sep 22;43(19):9564–9572. doi: 10.1093/nar/gkv944

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Thermodynamics profiles of combined beneficial spinach point mutations. (A) Combinatorial effect of two, three and seven beneficial point mutations on the functional and thermodynamic profile of Spinach. The 7 point mutation (PM) includes the mutations A12G, A15G, U18C, U21A, G36A, C49U, A75U. (B) Combination of the beneficial point mutations with the deletion of the U50 nucleotide (U50D) and knob region (KD). Combinatorial mutations of Spinach marked with an asterix showed a bimodal melting curve.