Table 1. Point mutations in mTOR from patients with ccRCC were annotated from the TCGA and represented by their respective domains.

amino acid	mutation	domain	amino acid	mutation	domain
G5R	missense	HEAT repeats	M1998I	missense	FRB
T314N	missense	HEAT repeats	V2006L	missense	FRB
V373L	missense	HEAT repeats	E2033V	missense	FRB
G438W	missense	HEAT repeats	A2210P	missense	kinase
A695S	missense	HEAT repeats	P2213L	missense	kinase
A695D	missense	HEAT repeats	S2215Y	missense	kinase
R755H	missense	HEAT repeats	L2220F	missense	kinase
K860N	missense	HEAT repeats	Q2223L	missense	kinase
T1046T	coding-silent	HEAT repeats	I2228T	missense	kinase
L1212L	coding-silent	HEAT repeats	L2230V	missense	kinase
M1313I	missense	HEAT repeats	M2327I	missense	kinase
A1428T	missense	FAT	L2334V	missense	kinase
L1433S	missense	FAT	V2406A	missense	kinase
K1452N	missense	FAT	D2412V	missense	kinase
A1459P	missense	FAT	V2417M	missense	kinase
L1460P	missense	FAT	V2422I	missense	kinase
Y1463S	missense	FAT	L2431P	missense	kinase
Y1463Y	coding-silent	FAT	I2500M	missense	kinase
C1483F	missense	FAT	I2501F	missense	kinase
C1483Y	missense	FAT	R2505P	missense	kinase
A1519T	missense	FAT	D2512H	missense	kinase
K1662M	missense	FAT	Q2524L	missense	FATC
W1705R	missense	FAT	E2526E	coding-silent	FATC
A1835A	coding-silent	FAT
Q1886Q	coding-silent	FAT
F1888I	missense	FAT
F1888L	missense	FAT
I1973F	missense	FAT
T1977K	missense	FAT
T1977R	missense	FAT