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. 2015 Jul 22;6(20):17968–17980. doi: 10.18632/oncotarget.4956

Figure 3. p53 R172H expression in cycling and proliferative cells of small intestinal crypts.

Figure 3

A. mutp53 expressed in cycling crypt base columnar (CBC) stem cells and proliferating transit-amplifying (TA) cells but is absent in differentiated Paneth cells and villous epithelia. Orange arrow: CBC stem cell, Brown arrow: proliferating TA cells. Cyanic arrow: Paneth cells, Blue arrow: villi. B. ex vivo cultures of intestinal crypts from p53 R172H mice mimic the gene dosage phenotype observed in vivo. C. Co-labelling of p53 and proliferative marker PCNA in p53 wild type and p53 R172H mouse small intestine. Scale bar: 20 μm.