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. 2015 May 23;6(20):18027–18037. doi: 10.18632/oncotarget.4090

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Copyright: © 2015 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. MTT assay was used to detect the effect of skp2 siRNA in combination with curcumin treatment on glioma cell proliferation. Both: curcumin + Skp2 siRNA. *P < 0.05, compared with control; ^#P < 0.05 compared with curcumin treatment or Skp2 siRNA transfection. B. Apoptosis was detected by Flow cytometry in glioma cells with Skp2 siRNA transfection and curcumin treatment. C. The wound healing assay was conducted to detect the cell migration in glioma cells after Skp2 siRNA transfection and curcumin treatment. SiRNA: Skp2 siRNA; Both: curcumin + Skp2 siRNA. *P < 0.05, vs control; ^#P < 0.05 vs curcumin treatment or Skp2 siRNA transfection. D. Invasion assay was performed in glioma cells after Skp2 siRNA transfection and curcumin treatment.