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a. All eight ALL cell lines showed marked decrease in proliferation after a 3 day treatment with CX-5461. b. 3 h treatment with CX-5461 reduced 45S pre-rRNA transcript in a dose dependent manner. Transcript levels were measured using quantitative PCR and normalized to the expression of GAPDH and Actin. (a, b) Experiments were repeated three times and error bars represent +/− S.D.
