Figure 6. CX-5461 shows synergy with ATR inhibitor.

a. SEM and KOPN-8 were treated as in (Figure 5C) for 2 days and apoptosis was measured with Annexin V staining. b. SEM and KOPN-8 cells were pre-treated with 0.05 μM VE-822 followed by 0.05 μM CX-5461 or with CX-5461 or VE-822 alone for 2 days. Annexin V was used to measure apoptosis. (a, b) All experiments were repeated three times and error bars represent +/− S.D.