Figure 1. Structural hierarchy of p62/SQSTM1 organization.
The presented p62 structures span the size range from 1 nm to 100s of nm. Left. Dimer model from p62 rat homologue (PDB 2KKC). Center. PB1 domains assemble into polymers as helical strands that pack against each other to form helical assemblies (PDB 4UF8, EMD-2936). Right. Helical polymers are thought to make up the bulk of p62 bodies inside eukaryotic cells.