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. 2015 Jul 15;6(19):16981–16997. doi: 10.18632/oncotarget.4858

Figure 2. High-throughput kinome shRNA screen reveals kinases that rescue constitutive mTORC1 activation in NF2-deficient human meningioma cells.

Figure 2

Ten kinases with an average robust z score of < −1.8 were identified by reduced immunofluorescence staining of pS6 (S240/244) (mTORC1 readout) after infection of Ben-Men-1 cells with individual kinase shRNAs. Each spot represents an average of 3 replicates, with > 2 hairpins for each top hit shown (encircled black triangles).