Table 1. Association between Defined Daily Dose and hepatic adverse drug reactions.

DDD Group (Drug Number)	DDD < 10 mg (n = 169)	10 ≤ DDD < 100 mg (n = 288)	DDD ≥ 100 mg (n = 518)	P-value
hADRs Type
Fatal hADRs	12 (7%)	35 (12%)	103 (20%)	1.31E-05***
Liver Failure	13 (8%)	58 (20%)	137 (26%)	3.42E-07***
Liver Transplantation	1 (1%)	8 (3%)	28 (5%)	2.41E-03**
Jaundice	36 (21%)	83 (29%)	190 (37%)	8.43E-05***
Biomarker Increase	23 (14%)	67 (23%)	161 (31%)	3.43E-06***
Hepatomegaly	6 (4%)	12 (4%)	43 (8%)	8.29E-03**
Hepatitis	27 (16%)	74 (26%)	190 (37%)	5.94E-08***
Severe hADRs	16 (9%)	60 (21%)	149 (29%)	1.53E-07***
All hADRs	60 (36%)	130 (45%)	288 (56%)	1.60E-06***

P value was determined using the Cochran-Armitage test.

^*P < 0.05

^**P < 0.01

^***P < 0.001