Table 1. Association between Defined Daily Dose and hepatic adverse drug reactions.
DDD Group (Drug Number) | DDD < 10 mg (n = 169) | 10 ≤ DDD < 100 mg (n = 288) | DDD ≥ 100 mg (n = 518) | P-value |
---|---|---|---|---|
hADRs Type | ||||
Fatal hADRs | 12 (7%) | 35 (12%) | 103 (20%) | 1.31E-05*** |
Liver Failure | 13 (8%) | 58 (20%) | 137 (26%) | 3.42E-07*** |
Liver Transplantation | 1 (1%) | 8 (3%) | 28 (5%) | 2.41E-03** |
Jaundice | 36 (21%) | 83 (29%) | 190 (37%) | 8.43E-05*** |
Biomarker Increase | 23 (14%) | 67 (23%) | 161 (31%) | 3.43E-06*** |
Hepatomegaly | 6 (4%) | 12 (4%) | 43 (8%) | 8.29E-03** |
Hepatitis | 27 (16%) | 74 (26%) | 190 (37%) | 5.94E-08*** |
Severe hADRs | 16 (9%) | 60 (21%) | 149 (29%) | 1.53E-07*** |
All hADRs | 60 (36%) | 130 (45%) | 288 (56%) | 1.60E-06*** |
P value was determined using the Cochran-Armitage test.
P < 0.05
P < 0.01
P < 0.001