Table 2. Association between LogP and hepatic adverse drug reactions.
LogP Group (Drug Number) | LogP < 1(n = 214) | 1 ≤ LogP < 3(n = 378) | LogP ≥ 3(n = 360) | P-value |
---|---|---|---|---|
hADR Type | ||||
Fatal hADRs | 35 (16%) | 46 (12%) | 68 (19%) | 2.35E-01 |
Liver Failure | 55 (26%) | 64 (17%) | 88 (24%) | 8.97E-01 |
Liver Transplantation | 9 (4%) | 8 (2%) | 20 (6%) | 2.41E-01 |
Jaundice | 69 (32%) | 98 (26%) | 141 (39%) | 2.43E-02* |
Biomarker Increase | 54 (25%) | 94 (25%) | 101 (28%) | 3.94E-01 |
Hepatomegaly | 19 (9%) | 23 (6%) | 19 (5%) | 1.04E-01 |
Hepatitis | 68 (32%) | 107 (28%) | 115 (32%) | 8.15E-01 |
Severe hADRs | 58 (27%) | 72 (19%) | 94 (26%) | 8.69E-01 |
All hADRs | 105 (49%) | 177 (47%) | 192 (53%) | 2.23E-01 |
P value was determined using the Cochran-Armitage test.
P < 0.05
P < 0.01
P < 0.001