Table 2. Association between LogP and hepatic adverse drug reactions.

LogP Group (Drug Number)	LogP < 1(n = 214)	1 ≤ LogP < 3(n = 378)	LogP ≥ 3(n = 360)	P-value
hADR Type
Fatal hADRs	35 (16%)	46 (12%)	68 (19%)	2.35E-01
Liver Failure	55 (26%)	64 (17%)	88 (24%)	8.97E-01
Liver Transplantation	9 (4%)	8 (2%)	20 (6%)	2.41E-01
Jaundice	69 (32%)	98 (26%)	141 (39%)	2.43E-02*
Biomarker Increase	54 (25%)	94 (25%)	101 (28%)	3.94E-01
Hepatomegaly	19 (9%)	23 (6%)	19 (5%)	1.04E-01
Hepatitis	68 (32%)	107 (28%)	115 (32%)	8.15E-01
Severe hADRs	58 (27%)	72 (19%)	94 (26%)	8.69E-01
All hADRs	105 (49%)	177 (47%)	192 (53%)	2.23E-01

P value was determined using the Cochran-Armitage test.

^*P < 0.05

^**P < 0.01

^***P < 0.001