Table 5. Interactions between oral dose and LogP, or oral dose and hepatic metabolism analyzed by logistic regression.

	Oral Dose × LogP			Oral Dose × Hepatic Metabolism
	Adjusted OR	95% CI	P-value	Adjusted OR	95% CI	P-value
Fatal hADRs	1.31	0.62–2.77	0.484	2.14	0.69–6.66	0.190
Liver Failure	1.44	0.75–2.78	0.270	1.12	0.45–2.8	0.800
Liver Transplantation	1.58	0.34–7.34	0.557	0.00	0.00–+∞	0.986
Jaundice	1.26	0.72–2.23	0.419	1.19	0.51–2.77	0.687
Biomarker Increase	1.44	0.78–2.66	0.240	1.32	0.56–3.1	0.532
Hepatomegaly	5.17	1.26–21.22	0.022*	2.79	0.69–11.25	0.149
Hepatitis	1.48	0.82–2.67	0.188	2.68	1.17–6.16	0.020*
Severe hADRs	1.17	0.62–2.22	0.627	1.16	0.47–2.86	0.755
All hADRs	1.15	0.67–1.97	0.610	1.40	0.66–2.95	0.382

The Wald test was used to determine the statistical significance of interacting variable in logistic regression. OR, odds ratio; CI, confidence interval.

^*P < 0.05

^**P < 0.01

^***P < 0.001