Table 5. Interactions between oral dose and LogP, or oral dose and hepatic metabolism analyzed by logistic regression.
Oral Dose × LogP | Oral Dose × Hepatic Metabolism | |||||
---|---|---|---|---|---|---|
Adjusted OR | 95% CI | P-value | Adjusted OR | 95% CI | P-value | |
Fatal hADRs | 1.31 | 0.62–2.77 | 0.484 | 2.14 | 0.69–6.66 | 0.190 |
Liver Failure | 1.44 | 0.75–2.78 | 0.270 | 1.12 | 0.45–2.8 | 0.800 |
Liver Transplantation | 1.58 | 0.34–7.34 | 0.557 | 0.00 | 0.00–+∞ | 0.986 |
Jaundice | 1.26 | 0.72–2.23 | 0.419 | 1.19 | 0.51–2.77 | 0.687 |
Biomarker Increase | 1.44 | 0.78–2.66 | 0.240 | 1.32 | 0.56–3.1 | 0.532 |
Hepatomegaly | 5.17 | 1.26–21.22 | 0.022* | 2.79 | 0.69–11.25 | 0.149 |
Hepatitis | 1.48 | 0.82–2.67 | 0.188 | 2.68 | 1.17–6.16 | 0.020* |
Severe hADRs | 1.17 | 0.62–2.22 | 0.627 | 1.16 | 0.47–2.86 | 0.755 |
All hADRs | 1.15 | 0.67–1.97 | 0.610 | 1.40 | 0.66–2.95 | 0.382 |
The Wald test was used to determine the statistical significance of interacting variable in logistic regression. OR, odds ratio; CI, confidence interval.
P < 0.05
P < 0.01
P < 0.001