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. 2015 Apr 19;6(19):17054–17064. doi: 10.18632/oncotarget.3881

Table 1. Significantly up-regulated genes in monocytes from aged vs. young rats.

Gene Description Fold change p FDR
Pnliprp2 Pancreatic lipase-related protein 2 372.49 0.00E+00 1.00E-05
Ispd Isoprenoid synthase domain-containing protein 366.83 0.00E+00 1.13E-03
Anxa8 Annexin A8 210.29 0.00E+00 1.70E-04
Gzmf Granzyme F 208.57 0.00E+00 3.24E-03
Sfrp1 Secreted frizzled-related protein 1 195.25 1.00E-05 3.24E-03
Cdh13 Cadherin 13 61.88 0.00E+00 3.10E-04
Lama3 Laminin alpha 3 57.29 3.00E-05 5.99E-03
Calb2 Calbindin 2 52.87 5.00E-05 7.68E-03
Thumpd1 THUMP domain-containing protein 1 40.75 0.00E+00 1.00E-05
Klrb1 Killer cell lectin-like receptor subfamily B member 1 40.66 3.00E-05 6.22E-03
Ppic Peptidyl-prolyl cis-trans isomerase C 34.04 1.80E-04 1.73E-02
Asam Adipocyte adhesion molecule 24.46 1.00E-05 3.24E-03
Lyzl4 Lysozyme A 22.60 9.00E-05 1.10E-02
Cdkn2a Cyclin-dependent kinase inhibitor 2A 21.33 2.00E-05 5.55E-03
Cela1 Chymotrypsin-like elastase family member 1 15.50 6.00E-05 8.58E-03
Lrrc72 Leucine-rich repeat-containing protein 72 12.78 1.00E-05 3.24E-03
Tnni1 Troponin I, slow skeletal muscle 12.60 4.80E-04 3.50E-02
Resp18 Regulated endocrine-specific protein 18 12.48 3.00E-04 2.63E-02
Nr4a3 Nuclear receptor subfamily 4 group A member 3 12.13 1.00E-05 4.56E-03
Dnah8 Dynein, axonemal heavy chain 8 11.74 1.30E-04 1.45E-02
Ephb3 Ephrin type-B receptor 3 11.41 2.00E-05 5.55E-03
Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 10.16 2.00E-05 5.55E-03
Mcam Cell surface glycoprotein MUC18 9.85 2.00E-05 5.35E-03
Mpp7 MAGUK p55 subfamily member 7 8.67 3.00E-05 6.33E-03
Actn2 Actinin alpha 2 8.53 7.80E-04 4.89E-02
Slc4a4 Electrogenic sodium bicarbonate cotransporter 1 8.42 1.00E-05 3.24E-03
Dusp2 Dual specificity protein phosphatase 2 8.19 3.00E-05 6.33E-03
Ifng Interferon gamma 6.45 2.00E-05 5.43E-03
Spag5 Sperm associated antigen 5 5.99 7.00E-04 4.52E-02
Pask PAS domain-containing serine/threonine protein kinase 5.93 7.00E-04 4.87E-02
Cldn23 Claudin 23 5.86 7.00E-05 9.12E-03
Gstt3 Glutathione S-transferase theta 3 5.75 5.40E-04 3.79E-02
Gfi1 Zinc finger protein Gfi-1 5.73 4.00E-05 6.77E-03
Lpar3 Lysophosphatidic acid receptor 3 5.65 1.00E-04 1.18E-02
Nol3 Nucleolar protein 3 5.62 1.30E-04 1.43E-02
Gzmbl3 Granzyme B-like 3 5.56 0.00E+00 2.46E-03
Copz2 Coatomer protein complex, subunit zeta 2 5.14 3.20E-04 2.68E-02
Kif20b M-phase phosphoprotein 1 5.04 6.20E-04 4.15E-02
Nr4a2 Nuclear receptor subfamily 4 group A member 2 5.00 5.00E-05 7.84E-03
Myh2 Myosin, heavy chain 2 4.95 4.50E-04 3.35E-02
Cks1b Cyclin-dependent kinases regulatory subunit 1 4.83 4.10E-04 3.16E-02
Spc25 Kinetochore protein Spc25 4.72 6.30E-04 4.22E-02
Arhgef39 Rho guanine nucleotide exchange factor 39 4.51 4.00E-04 3.13E-02
Gfra2 GDNF family receptor alpha-2 4.47 5.20E-04 3.71E-02
Plk3 Serine/threonine-protein kinase PLK3 4.47 2.00E-05 5.36E-03
Plk2 Serine/threonine-protein kinase PLK2 4.43 2.00E-05 5.35E-03
Dapk2 Death-associated kinase 2 4.35 3.40E-04 2.78E-02
Agpat3 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma 4.34 2.20E-04 2.00E-02
Tmem246 Transmembrane protein 246 4.33 1.00E-05 4.56E-03
Scin Adseverin 4.32 1.70E-04 1.69E-02
Esam Endothelial cell-selective adhesion molecule 4.21 3.60E-04 2.93E-02
Cks2 Cyclin-dependent kinases regulatory subunit 2 4.18 8.00E-05 1.07E-02
Sgca Alpha sarcoglycan 4.18 3.10E-04 2.66E-02
Rasl11b Ras-like protein family member 11B 4.15 7.00E-05 9.12E-03
Csf1 Macrophage colony-stimulating factor 1 4.11 4.50E-04 3.35E-02
Fv1 Friend virus susceptibility protein 1 4.07 4.70E-04 3.46E-02
Chn2 Beta-chimaerin 4.01 4.40E-04 3.34E-02
Ube2t Ubiquitin-conjugating enzyme E2T 3.95 5.10E-04 3.76E-02
Xxylt1 Xyloside xylosyltransferase 1 3.95 6.00E-05 8.91E-03
Srpk3 Serine/arginine-rich splicing factor protein kinase 3 3.90 4.00E-05 6.56E-03
Prc1 Protein regulator of cytokinesis 1 3.82 7.40E-04 4.72E-02
Cxcl1 Chemokine (C-X-C motif) ligand 1 3.76 7.60E-04 4.81E-02
Mfsd4 Major facilitator superfamily domain-containing protein 4 3.74 7.00E-05 9.23E-03
Cd24 Signal transducer CD24 3.68 5.80E-04 3.98E-02
Gprc5a Retinoic acid-induced protein 3 3.63 3.40E-04 2.80E-02
Mark1 Serine/threonine-protein kinase MARK1 3.61 1.00E-04 1.22E-02
Rgs16 Regulator of G-protein signaling 16 3.61 1.00E-04 1.18E-02
Gmnn Geminin 3.54 2.00E-04 1.90E-02
Chrne Acetylcholine receptor subunit epsilon 3.45 1.90E-04 1.80E-02
Calcr Calcitonin receptor 3.41 7.30E-04 4.66E-02
Sccpdh Saccharopine dehydrogenase-like oxidoreductase 3.37 4.00E-04 3.14E-02
Pik3r1 Phosphoinositide-3-kinase, regulatory subunit 1 alpha 3.36 5.30E-04 3.77E-02
Ly49i4 Ly49 inhibitory receptor 4 3.35 4.50E-04 3.35E-02
Slco4a1 Solute carrier organic anion transporter family member 4A1 3.23 1.30E-04 1.43E-02
Ppp1r36 Protein phosphatase 1, regulatory subunit 36 3.04 7.00E-04 4.52E-02
Pla2g2f Group IIF secretory phospholipase A2 3.03 3.20E-04 2.70E-02
Syne1 Spectrin repeat-containing, nuclear envelope protein 1 2.97 6.60E-04 4.34E-02
Egr1 Early growth response protein 1 2.95 7.00E-04 4.52E-02
Gels Gelsolin 2.92 1.30E-04 1.43E-02
Wdr25 WD repeat-containing protein 25 2.90 1.80E-04 1.73E-02
Prdm1 PR domain zinc finger protein 1 2.82 4.80E-04 3.50E-02
Jun Transcription factor AP-1 2.73 1.40E-04 1.51E-02
Grk4 G protein-coupled receptor kinase 4 2.42 6.20E-04 4.15E-02
Lmnb1 Lamin B1 2.39 6.20E-04 4.15E-02
Btg3 Protein BTG3 2.19 7.30E-04 4.66E-02