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. 2015 Feb 18;6(19):17121–17134. doi: 10.18632/oncotarget.2736

Figure 6. Effects of SNAI2-gene transfection on the expression of neuroendocrine differentiation-, metastasization- and pluripotency-associated genes in DU145 cells.

Figure 6

Western Blot analyses showed that, in SNAI2-gene transfected DU145 cells, SNAI2 protein expression was up-regulated by 259% (adjusted to β-actin). Real-time RT-PCR showed that CHGA and SYP were up-regulated by 222%, and 208%, respectively. Within the stemness-related genes, the expression levels of SOX2, CD44v6 and NOTCH1, along with that of WWTR1/TAZ, increased by 183%, 210%, 182%, and 181%, respectively. Cyclin D1 was up-regulated by 227%, whereas KISS1 and CDH1 were down-regulated by 72%, and 66%, respectively. *p < 0.05 Student's t-test compared with Ctrl cells.