Table 1. IC₅₀ Values of Chemotherapeutics in A549 Cells.

Chemotherapeutic Agent	Scramble	PAPSS1 Knockdown	p-value
Mitotic Inhitibors
Vincristine	29.0 nM	32.0 nM	ns
Docetaxel	0.54 μM	0.61 μM	ns
DNA Crosslinkers
Cisplatin	2.44 μM	0.44 μM	p < 0.05
Carboplatin	30.0 μM	10.2 μM	p < 0.05
Oxaliplatin	3.31 μM	1.41 μM	p < 0.05
Mitomycin C	68.2 nM	16.5 nM	p < 0.05
Topoisomerase I Inhibitors
Topotecan	78.9 nM	37.8 nM	p < 0.05
Irinotecan	9.7 μM	4.3 μM	p < 0.05
Topoisomerase II Inhibitors
Doxorubicin	83.5 nM	71.9 nM	ns
Epirubicin	69.0 nM	51.9 nM	ns

ns = IC₅₀ values between control and PAPSS1-silenced cells are not statistically significant