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. 2015 Apr 29;6(19):17251–17260. doi: 10.18632/oncotarget.3949

Figure 7. Inhibitory effect of 1,5-isoquinolinediol (IQD) on PARP1 activity.

Figure 7

A. Murine embryonic fibroblasts were treated with IQD at passage number 2 and 6. PARP1 was immunoblotted to verify the expression level, and the expression of lamin A was assessed to monitor replicative senescence. Tubulin was used as a loading control. B. Conceptual diagram to explain the anti-senescence effect of IQD. In basal replicative senescence conditions or oxidative stress, PARP1 is activated and is associated with biological aging in the different tissues. Treatment with IQD partially ameliorates the rate of senescence.