Table 1. GEP changes following HDAC inhibition in myeloma cells.
| Probe ID | Gene | Fold change | ||
|---|---|---|---|---|
| APi | HDACi | Combination | ||
| 210538_s_at | BIRC3 3 | 49.17 | 23.51 | 110.62 |
| 202644_s_at | A20 | 14.63 | NS | 16.64 |
| 201502_s_at | IκBα | 4.93 | NS | 6.55 |
| 221903_s_at | CYLD | 2.04 | 2.47 | 4.16 |
H929 cells were treated with tosedostat (CHR-2797) 1 μM (APi), CHR-3996 250 nM (HDACi), or a combination of both for 24 hours then analysed on a U133 Plus 2.0 Array (Affymetrix) and a supervised analysis performed with dCHIP comparing the groups of treated cells to untreated cells. All p values were less than 0.05. NS, no significant change.