Table 3. The Cox regression analyses of Disease-free survival (DFS) and TMEM100 expression level as well as clinicopathological parameters.

	Univariable analysis		Multivariable analysis
Variables	HR (95% CI)	P	HR (95% CI)	P
Gender(Male vs. Female)	0.912 (0.387 - 1.981)	0.513
Age(≤60 vs. > 60 )	0.778 (0.342 – 2.711)	0.611
HBsAg(Negative vs. Positive)	0.882 (0.621 - 2.629)	0.571
Cirrhosis(Presence vs. Absence)	1.758 (1.241 - 7.642)	0.038	1.708 (0.898 – 4.824)	0.061
Child-Pugh Score(Grade A vs. B)	0.821 (0.392 - 2.231)	0.772
AFP level(ng/ml, ≤ 20 vs. > 20)	0.736 (0.229 - 1.791)	0.338
Tumor size(>5 vs. ≤5 cm)	1.847 (0.872 - 2.932)	0.119
Capsular formation(Presence vs. Absence)	0.621 (0.423 – 1.118)	0.082	0.808 (0.232 – 1.635)	0.649
Tumor nodule number(Solitary vs. Multiple)	0.483 (0.288 – 0.896)	0.036	0.421 (0.244 – 0.985)	0.028
Edmondson-Steiner Stage(I-II vs. III-IV)	0.462 (0.311 – 1.276)	0.242
Vein invasion(Presence vs. Absence)	1.586 (1.112 – 2.783)	0.013	1.898(1.087 – 3.824)	0.017
TMEM100 expression(Low vs. High)	2.128 (1.132 – 5.217)	0.009	2.612 (1.227 – 4.561)	0.026