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. 2015 May 7;6(19):17661–17674. doi: 10.18632/oncotarget.3756

Figure 5. E-cadherin exerts feedback regulation on RBP2 expression by inhibiting Smad3 phosphorylation; Co-expression of RBP2 and Snail-1 and their inverse relationship with E-cadherin expression in primary gastric cancer tissues in vivo.

Figure 5

a. E-cadherin depletion upregulates the expression of p-smad3 and thus promotes RBP2 induction. Representative images are shown here from three independent biological replicates. b. E-cadherin knockdown enhances GC cell migration, similar to the effect of RBP2 induction. Data are mean±SD of 3 biological replicates, **p < 0.01 compared with negative control. Original magnification, × 40. c. and d. Co-expression of RBP2 and Snail-1 in invasive and metastatic gastric cancer tissues respectively where E-cadherin expression is lost. Representative images are shown here. Original magnification, × 40 (enlarged × 4). e. Inverse correlation between RBP2 and E-cadherin expression in the above tissues. f. Inverse correlation between Snail-1 and E-cadherin expression in the above tissues. g. Summary of the main positive feedback regulation circuit delineated in this paper.