Figure 4. Effect of lapatinib on pharmacokinetics of paclitaxel and doxorubicin.
A. B. Effect of lapatinib on the profile of paclitaxel and doxorubicin pharmacokinetics in mice. NIH mice were p.o. administered with or without lapatinib (100 mg/kg) 1 h before i.v. administration of paclitaxel (18 mg/kg) or doxorubicin (10 mg/kg). HPLC analysis was performed as described in the “Material and Methods”. The values represent mean ± standard deviation in the triplicate determination.