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. 2015 Apr 23;6(19):17738–17752. doi: 10.18632/oncotarget.3921

Figure 4. Effect of lapatinib on pharmacokinetics of paclitaxel and doxorubicin.

Figure 4

A. B. Effect of lapatinib on the profile of paclitaxel and doxorubicin pharmacokinetics in mice. NIH mice were p.o. administered with or without lapatinib (100 mg/kg) 1 h before i.v. administration of paclitaxel (18 mg/kg) or doxorubicin (10 mg/kg). HPLC analysis was performed as described in the “Material and Methods”. The values represent mean ± standard deviation in the triplicate determination.