Table 3. Mean values of liver function tests in Swiss mice hepatotoxicity model.

Group	ALT(U/L)	AST(U/L)	UA(mg/dL)	ALP(U/L)	LDH(U/L)	BUN(U/L)	CRE(μmol/L)	GLOB(mmol/L)
Control	28.22 ± 6.72	99.27 ± 11.44	286.4±64.6	218.51 ± 51.01	1542.05 ± 404.84	9.59 ± 1.14	17.87 ± 2.16	14.85 ± 0.25
Lapatinib	32.05 ± 5.57	99.59 ± 15.55	271.0±78.7	234.96 ± 54.33	1732.88 ± 489.41	10.95 ± 1.62	18.47 ± 2.19	14.1 ± 0.35
Paclitaxel	33.90 ± 6.09	97.94 ± 23.46	237.3±72.8	192.35 ± 32.12	1540.83 ± 457.35	9.82 ± 1.38	15.77 ± 1.78	14.12 ± 0.44
Paclitaxel + lapatinib	59.97 ± 26.72 *	107.10 ± 28.67	317.8±75.4	213.29 ± 53.45	1808.00 ± 610.33	10.23 ± 0.97	15.39 ± 1.85 *	17.95 ± 0.27
Doxorubicin	22.19±15.00	84.71±11.08	440.27±78.04 *	112.3±6.91	1606.32±505.09	7.91±0.82	20.17±7.14	18.74±1.83
Doxorubicin+ lapatinib	20.43±8.61	101.44±10.98	523.42±50.73 **	113.85±18.66	1691.27±623.47	8.00±0.90	20.6±5.50	20.80±1.97 *

The P value was calculated by student t test. The values represent mean ± standard deviation in the triplicate determination.

^*P < 0.05

^**P < 0.01 for values versus those in control.