Table 2. Univariate and multivariate analysis for recurrence and OS by Cox regression models.

Parameter	Univariate Analysis			Multivariate Analysis
	HR	95% CI	P	HR	95% CI	P
Predictor: recurrence
Age(>60 years)	1.17	1.08–2.11	0.017	1.13	1.04–1.96	0.027
Sex (male)	0.83	0.50–2.11	0.713	—
Cause(HBV)	1.64	0.95–2.87	0.076	—
Viral status	2.30	1.20–4.21	0.011	2.01	1.09–4.09	0.029
Tumor number	1.29	1.02–2.31	0.673	—
Tumor size	1.78	1.31–3.24	0.021	1.54	1.24–2.91	0.038
Venous invasion	2.11	1.49–4.99	<0.001	1.87	1.32–3.06	0.002
TNM stage	3.23	1.46–7.32	0.001	2.08	1.22–4.15	0.006
Child-Pugh class	2.21	1.66–4.87	<0.001	2.01	1.51–4.31	<0.001
Presence of PVT	3.55	2.62–4.87	<0.001	1.78	1.21–2.65	0.003
Presence of extrahepatic	4.04	3.01–5.77	<0.001	1.85	1.28–2.62	0.001
AFP(>20 ng/ml)	2.07	1.42–3.01	0.008	1.88	1.27–3.98	0.011
Hs-CRP(>0.4 mg/dl)	2.18	1.71–4.45	<0.001	1.79	1.36–3.39	0.008
TrxRa	10.23	4.14–30.76	<0.001	4.19	3.21–7.08	<0.001
Predictor: OS
Age(>60 years)	1.69	1.34–3.04	0.019	1.44	1.13–2.56	0.036
Sex (male)	0.69	0.35–1.34	0.241	—
Cause(HBV)	1.54	1.06–3.21	0.097	—
Viral status	1.24	1.07–3.32	0.332	—
Tumor number	1.42	1.02–1.98	0.110	—
Tumor size	1.99	1.25–4.09	0.012	1.79	1.18–3.04	0.018
Venous invasion	2.11	1.49–3.59	<0.001	1.57	1.21–2.87	0.002
TNM stage	2.24	1.22–4.02	<0.001	2.11	1.42–3.29	0.001
Child-Pugh class	2.06	1.42–2.91	<0.001	2.00	1.55–4.26	<0.001
Presence of PVT	3.95	2.90–5.23	<0.001	1.66	1.08–2.75	0.022
Presence of extrahepatic	3.05	2.22–4.19	<0.001	1.62	1.13–2.26	0.008
AFP(>20 ng/ml)	2.19	1.09–4.32	0.028	1.94	1.10–3.77	0.038
Hs-CRP(>0.4 mg/dl)	3.06	1.66–5.63	<0.001	2.49	1.54–4.06	<0.001
TrxRa	16.15	6.11–39.65	<0.001	5.56	3.42–10.21	<0.001

^aincrease per log unit(thus, a log-transformed increase of 1 corresponds to a TrxR increase of 10 U/mL)

OS = Overall survival; CI = confidence intervals; HR = hazard ratios; HBV = hepatitis B virus; PVT = portal vein thrombosis; AFP = α-fetoprotein; Hs-CRP = High-sensitivity-C-reactive protein; TrxR = Thioredoxin reductase.