Skip to main content
. 2015 Jul 28;138(10):2987–3002. doi: 10.1093/brain/awv212

Figure 5.

Figure 5

Regional and neurochemical analysis of dystonia in DRD mice (n = 4–5/condition). (A) Microinjection of l-DOPA (200 pg) into the striatum of DRD mice significantly reduced abnormal movements [F(2,8) = 6.8, one way repeated measures ANOVA; P < 0.01 Holm Sidak post hoc analysis], whereas cerebellar microinjections did not (P > 0.1, Holm Sidak post hoc analysis). (B) Peripheral administration of 1 g/kg l-DOPS did not affect abnormal movements in DRD mice (P > 0.4, Student’s t-test). Microinjection experiments were performed at 2 pm and l-DOPS experiments were performed at 8 pm. Values represent mean ± SEM; **P < 0.05.